Each square holds 1, 2, 3 and 4 dots in its four quarters. Count your way round each square. Which one is the odd one out?

In (c), (d) and (e), and in (b) too, the counts go 1, 2, 3, 4 when you move CLOCKWISE from the quarter with 1 dot, wherever that quarter is. In (a) the 1 is at the top-right and moving clockwise gives 1, 4, 3, 2: the counts go up anticlockwise instead, so (a) is the odd one out.